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Helicases Maintain Genome Stability in Schizosaccharomyces Pombe Ding Lin

Helicases Maintain Genome Stability in Schizosaccharomyces Pombe

Ding Lin

Published May 20th 2014
ISBN : 9783639714166
Paperback
176 pages
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 About the Book 

Helicases Maintain Genome Stability In Schizosaccharomyces Pombe A healthy cell needs to accurately duplicate its genome and pass one copy to each of its daughter cells. The DNA double helix is accessed by replication machinery once per cell cycleMoreHelicases Maintain Genome Stability In Schizosaccharomyces Pombe A healthy cell needs to accurately duplicate its genome and pass one copy to each of its daughter cells. The DNA double helix is accessed by replication machinery once per cell cycle during S phase and regulated unwinding of this molecule is essential for replication. However, helicase-mediated unwinding can make the DNA vulnerable to damage or breakage. Therefore, the process of unwinding must be carefully regulated.